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KMID : 1161420200230111146
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Journal of Medicinal Food
2020 Volume.23 No. 11 p.1146 ~ p.1154
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Efficacy of Ethanolic Extract of Opuntia ficus-indica var. saboten Stems for Improving Cognitive Function in Elderly Subjects 55?85 Years of Age: A Randomized, Double-Blind, Placebo-Controlled Study
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Han Eun-Hye
Lim Mi-Kyung
Lee So-Yeon
Lee Sang-Ho
Yun Su-Min
Yu Heui-Jong
Ryu Seung-Ho
Lim Young-Hee
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Abstract
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Many natural compounds have been reported to improve cognitive function in cell- and animal-based studies. In this clinical trial, we evaluated the efficacy of ethanolic extract of Opuntia ficus-indica var. saboten stem for improving cognitive function using a randomized, double-blind, placebo-controlled trial (n?=?81) in aged people. After 12 weeks of administration of OFE (a mixture of ethanolic extract of O. ficus-indica var. Saboten stem and dextrin) or placebo, the effect on cognitive function was assessed. Overall, OFE did not show a significant difference from the placebo in terms of efficacy. However, the cognitive function significantly improved in the OFE group compared with the placebo group in the subgroup ≤70 years of age, which means that the effect of OFE administration exhibits an age-dependent effect. In addition, the safety of OFE was confirmed by analyzing blood test results, vital signs, and electrocardiograms. In conclusion, OFE administration in participants ≤70 years of age shows a positive effect on overall cognitive function. The trial was registered on CRIS (the Clinical Research Information Service), administered by the Korea Centers for Disease Control & Prevention (Registration Number: KCT0003766; URL: https://cris.nih.go.kr/cris/en/search/search_result_st01.jsp?seq=12957).
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KEYWORD
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cognitive function, double blind, Opuntia ficus-indica var. saboten stem, placebo-controlled study, randomized trial
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